Repair of porcine articular cartilage defect with a biphasic osteochondral composite
نویسندگان
چکیده
منابع مشابه
A three-dimensional osteochondral composite scaffold for articular cartilage repair.
There is a recognized and urgent need for improved treatment of articular cartilage defects. Tissue engineering of cartilage using a cell-scaffold approach has demonstrated potential to offer an alternative and effective method for treating articular defects. We have developed a unique, heterogeneous, osteochondral scaffold using the TheriForm three-dimensional printing process. The material co...
متن کاملRepair of porcine articular cartilage defect with autologous chondrocyte transplantation.
Articular cartilage is known to have poor healing capacity after injury. Autologous chondral grafting remains the mainstay to treat well-defined, full-thickness, symptomatic cartilage defects. We demonstrated the utilization of gelatin microbeads to deliver autologous chondrocytes for in vivo cartilage generation. Chondrocytes were harvested from the left forelimbs of 12 Lee-Sung pigs. The cell...
متن کاملBiomimetic biphasic scaffolds for osteochondral defect repair
The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed. Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues. For osteochondral reconstruction, one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone. Therefore, the biphasic scaffolds with the mimic structure...
متن کاملRepair of Porcine Articular Osteochondral Defects
Introduction: Our previous study showed that porcine articular osteochondral defects at non-weight bearing area could be repaired by autologous induced bone marrow stromal cells (BMSCs) and scaffold, which provided the direct evidence that BMSCs could differentiate into chondrocytes and osteoblasts respectively in different local environment . This study tests the possibility of repairing porci...
متن کاملUsing Xenogenic (Calf Foetal) Osteochondral Transplantation for Articular Cartilage Defect in Rabbit Model
Background: The destruction of articular cartilage is the major cause of articular problems. The articular cartilage has little repair postertial due to lack of perichondrium and direct blood circulation. It is, therefore important to consider this phenomena in surgical treatments. One of the articular cartilage reconstructive surgeries is using Osteo-Chondral graft. The main purpose of this re...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2007
ISSN: 0736-0266
DOI: 10.1002/jor.20442